biorisk management
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It is associated to biological toxins or infectious agents
Biorisk • sources may be: Unintentional exposure to unauthorized access Accidental release/ loss Theft Misuse Intentional unauthorized Diversion
Biorisk management is according to
CWA 15793: 2011
A system or process to control safety and security risks associated with the handling or storage and disposal of biological agents and toxins in laboratories and facilities
Biorisk management according to CWA 15793 • scopes includes: Identification of biological hazards Understanding potential impacts Management and mitigation of associated risks
What are the 3 components of biorisk management
Assessment Mitigation Performance evaluation *it is like a three-legged stool, a biorisk management system fails if one of the components or legs is overlooked or not addressed
true or false: a biorisk management system fails if one of the components or legs is overlooked or not addressed
true
what does AMP focuses on with equal attention
MATA: Mitigation Avoidance Transference Acceptance MALTA: Mitigation Avoidance Transference Limitation Acceptance *most common is mitigation
it is the initial step in implementing a biorisk management process relies on risk assessment
management risk assessment - includes identification of hazard and characterization of risks that are possibly present in the laboratory
Refers to anything in the environment that has the potential to cause harm
Hazard
Generally defined as a possibility that something bad or unpleasant will happen
Risk
What are the 4 risk assessment
Define the situation: - identify the hazards and risks of the biological agents to be handled - at-risks hosts, who cld be humans or animals inside and outside the lab must be identified Define the risk: - includes a review of how individuals inside and outside the lab may be exposed to hazards - either through droplets, inhalation, ingestion or inoculation Characterize the risks: - characterize the overall biosafety risks, the risk assessment team needs to compare the likelihood and consequences of infection Determine if the risks is acceptable or not: - takes into account the adequacy of any existing controls and deciding whether or not biorisk is acceptable
Identify the risk assessment: Must idenfitify the hazards and risks of the biological agents to be handled
Define the situation
Identify the risk assessment: Include a review of how individuals inside and outside the laboratory may be exposed to hazards. Either through droplets, inhalation, ingestion, or inoculation
Define the risks
Identify the risk assessment: Characterize the overall biosafety risks, the risk assessment team needs to compare the likelihood and consequences of infection
Characterize the risks
Identify the risk assessment: Takes into account the adequacy of any existing controls and deciding whether or not biorisk is acceptable
Determine if the risk is acceptable or not
Actions and control measures that are put into place to reduce or eliminate the risks associated with biological agents and toxins
Mitigation procedures - second fundamental component of biorisk management model
What are the 5 major control (Hierarchy of Controls)
Elimination: - most difficult and most effective - involves the total decision not to work w specific biological agent or even not doing the intended work - provides the highest degree of risk reduction Substitution: - replacement of the procedure or biological agent w a similar entity to reduce the risk Engineering controls: - includes physical changes in work stations, equipment, production, facility or any other relevant aspects of the work environment Administrative control: - refers to policies, standards and guidelines used to control risks - proficiency and competency training for lab stuff PPE: - worn by workers to protect them against chemicals, toxins and pathogenic hazards - emphasized by Salerno (2003) *not one of the mitigation controls or measures is completely effective at controlling or reducing all risks
Identify the Major control in mitigation procedures: Involves the total decision not to work with specific biological agent or even not doing the intended work
Elimination
Identify the Major control in mitigation procedures: Provides the highest degree of risk reduction
Elimination
Identify the Major control in mitigation procedures: Replacement of the procedure or biological agent with similar entity to reduce the risk
Substitution
Identify the Major control in mitigation procedures: Includes physical changes in work stations, equipments, production, facility, or any other relevant aspects of the work environment
Engineering controls
Identify the Major control in mitigation procedures: Refers to policies, standards, and guidelines used to control risks
Administrative controls
Identify the Major control in mitigation procedures: Proficiency and competency training for laboratory stuff
Administrative controls
Identify the Major control in mitigation procedures: Devices worn by workers to protect them against chemicals, toxins, and pathogenic hazards in the laboratory
Personal protective equipment PPE
who emphasized the mitigation procedures
Salerno (2003)