Drosophila eye development
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What is eyeless a homolog of?
Pax6
What causes aniridia?
Mutations in pax
What are the photoreceptor organs called?
Ommatidia
What is each ommatidium made up of?
8 photoreceptor neurons 4 cone cells 8 additional pigment cells
What direction does the morphogenetic furrow move in?
Sweeps over eye imaginal disc in a posterior to anterior fashion
What happens as the furrow moves forward?
Cell clusters appear behind it- differentiate into ommatidia
What does Spitz bind to?
DER receptors on neighbouring cells- R3,4 and R1,6
What is absolutely required in R7?
Sev
What is absolutely required in R8?
Boss
What is sev?
Sevenless= trans-membrane receptor tyrosine kinase, found in prospective R7 cells
What is boss?
Boss is sev’s ligand
What cells are ommatidia associated with?
bristle cell neuron socket sheath
What does -/+ pax6 mutation in mice cause?
Small eyes
What does a -/- pax6 mutation in mice cause?
Loss of eyes