Muscle 1
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How are skeletal muscle fibres created?
In utero by myoblasts
What are muscles?
Bundles of fibres encased in connective tissue sheaths
What do satellite cells do?
Replace cells after injury
What is a sarcomere?
The basic unit of striated muscle tissue
After an action potential has been fired in the muscle, calcium ions are released from the
Sarcoplasmic reticulum
What do calcium ions bind to?
Troponin on the actin filament
What is a skeletal muscle cell
A multinucleate muscle fibre
Describe the growth and repair of skeletal muscle
They are formed in utero by mononucleate myoblasts Their fibre size increases during growth Myoblasts do not replace cells if damaged Instead satellite cells replace cells after injury
What do tendons do?
Attach muscle to bone
Why do muscle fibres undergo hypertrophy?
To compensate when muscle fibres are injured
What is meant by hypertrophy?
Increase in size of skeletal muscle
Describe what happens during muscle contraction?
Calcium ions released from the sarcoplasmic reticulum bind to troponin This moves tropomyosin Myosin (with its ADP + Pi) can then bind to the actin filament Myosin then unbinds ADP + Pi ATP then binds to myosin and myosin unbinds from the actin filament
Describe what happens to the length of different components during muscle contraction?
Muscle shortens Sarcomere shortens Myosin stays the same length Space between myosin filaments decreases Space between actin filaments decrease
What does tropomyosin do?
Partially covers myosin binding sites on actin, held in blocking position by troponin
What is the motor unit?
Motor neurons + muscle fibres
State what is meant by tension
Force exerted by muscle
State what is meant by load
Force exerted on muscle
Define an isometric twitch
Contraction with constant length (e.g. weightlifting)
Define an isotonic twitch
Contraction with shortening length (e.g running)
Lengthening means
Contraction with increasing length
What causes a twitch?
A single action potential sent to a muscle fibre
What is contraction time dependent on?
Calcium ion concentration
What is the latent period?
The time before the excitation contraction starts
Describe the latent period and contraction event of isometric contraction?
Shorter latent period Longer contraction event