Clinical Chemistry 3

 to measure biological analytes in pathology specimens  results help in diagnosis, screening, prognosis and monitoring treatment

a set of instructions which describe the procedure, materials and equipment necessary to obtain a result

the process of relating the value indicated on the scale of an instrument or analytical device to the quantity required to be measured

a material or solution with which the sample is compared in order to determine a result

this is treated exactly as a sample or standard but does not contain the analyte to be measured and used to zero instruments

a material or solution which contains a known quantity of the analyte of interest and is used for quality control purposes

 reliability  practicality

 analytical variation  biological variation

 this is the ability of a method to give results which are close to the true value of the substance being measured

this is the ability of a method to provide the same value every time the method is used to measure a particular analyte in the same specimen

this is the ability of a method to detect small amounts of the analyte

the smallest amount of the analyte that can be distinguished from the blank

this is the ability of a method to detect only the test substance

 sex  age  diet  time of day  posture  stress  exercise  menstrual cycle  drugs

 speed  cost  skillrequirements  dependability  safety

 Analytical methods used to obtain results when investigating disease  Analytical methods must meet reliability and practicality criteria before being used on a routine basis