Body Compartments And Drug Movement C
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How are lipid insoluble drugs carried around the body?
They are carried by transporters that are physiologically important molecules of the body ; glucose, amino acids, neurotransmitters, ions.
What are the 3 solute carriers that transport drugs?
Uniporter Antiporter Symporter
What are uniporter, symporters and antiporters?
Solute carriers (SLC)
What are the two types of SLC?
Organic cation transporters (OCTs) -Drugs that are weak bases Organic anion transporters (OATs) - Drugs that are weak acids
How do antiporters and symporters work?
secondary active transport by (Energy dependent carriers)
What do p-glycoproteins do?
They pump foreign substances out of cells, so reduce drug concentration at treatment targets which hence reduces efficacy. They also transport many different drugs.
What impairs the function of p-glycoproteins transporters (P-gp)?
• Drugs that block transporter function (causing drug interactions) • Mutations that change transporter function
What type of transporter is an effluent pumps?
An ABC carrier (ATP-binding cassettes)
What does an efflux pump use to work?
ATP hydrolysis. ATP is converted into ADP.
What mechanism does an Efflux pump operate under?
Primary active transport by ATP dependent carriers
What process do uniporters use?
Facilitated diffusion.
What processes do solute carriers use?
Facilitated diffusion and secondary active transport.
What processes do ATP-binding cassettes use?
Channels and primary active transport by ATP-dependent carriers.
What process does a uniporter use?
Facilitated diffusion.
What is a uniporter?
It moves molecules along its concentration gradient in one direction.
What is an antiporter?
It transports two or more molecules in opposite directions (swapped)
What is a symporter?
The drug and molecule are transported together.