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4. Iron Studies

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Total cards: 24•Content version: v4•Public deck•Updated: 8/1/2026

Card preview (24)

#1
Front (Question)

Excess in later intermediates (URO, COPRO, PROTO) of porphyrin/heme synthesis pathway causes ________ symptoms

Back (Answer)

cutaneous

#2
Front (Question)

How to distinguish true from secondary porphyrias?

Back (Answer)

Measure urinary ALA and PBG. In secondary: • ALA increased • PBG normal

#3
Front (Question)

Porphyrin compound excreted in urine

Back (Answer)

URO

#4
Front (Question)

Present in early childhood w/ extreme photosensitivity

Back (Answer)

Congenital erythropoietic porphyria (CEP)

#5
Front (Question)

Presence of an isomer of COPRO (isocoproporphyrin) is distinctive of PCT in this test

Back (Answer)

Fecal porphyrins

#6
Front (Question)

Increased in all porphyrias except in Acute Intermittent Porphyria

Back (Answer)

Fecal porphyria

#7
Front (Question)

Porphyrin compound excreted in feces

Back (Answer)

PROTO

#8
Front (Question)

What happens to oxygen when there is a RIGHT shift?

Back (Answer)

Hgb more likely to RELEASE O2 to tissues (decreased oxygen affinity of Hgb)

#9
Front (Question)

Enzyme deficiency in PP

Back (Answer)

Ferrochelatase

#10
Front (Question)

Low iron in anemia of chronic illness is due to?

Back (Answer)

Macrophages holding back iron availability for RBC production

#11
Front (Question)

Enzyme deficiency in HCP

Back (Answer)

Coprophyrinogen oxidase

#12
Front (Question)

Enzyme deficiency in CEP

Back (Answer)

Uroporphyrinogen III synthase

#13
Front (Question)

Porphyrin compound excreted in EITHER urine or feces

Back (Answer)

COPRO

#14
Front (Question)

Irreversrible chemical alteration of hemoglboin

Back (Answer)

Sulfhemoglobin

#15
Front (Question)

Early indicator of hemochromatoesis

Back (Answer)

Increased ferritin

#16
Front (Question)

Most common type of porphyria; remains dormant until some form of liver dysfunction

Back (Answer)

Porphyria cutanea tarda (PCT)

#17
Front (Question)

Most hemoglobin is degraded via this pathway

Back (Answer)

Extravascular hemolysis

#18
Front (Question)

What causes the formation of methemoglobin?

Back (Answer)

Oxidation of ferrOus to ferrIC iron in hgb = cannot reversibly bind oxygen

#19
Front (Question)

Colour of carboxyhemoglobin?

Back (Answer)

Bright cherry red

#20
Front (Question)

Free erythrocyte protoporphyrin (FEP) reflects concentrations of __________

Back (Answer)

zinc protoporphyrin (ZPP)

#21
Front (Question)

2 neurocutaneous porphyrias?

Back (Answer)

• Hereditary coproporphyria (HCP) - Variegate porphyria (VP)

#22
Front (Question)

2 most common SCREENING tests based on PBG (porphobilinogen) forming red-orange color when mixed with Ehrlichs

Back (Answer)

• Watson-Schwarz - Hoesch

#23
Front (Question)

%SO2 formula

Back (Answer)

%SO2 = O2hgb/(O2hgb + HHgb) * 100%

#24
Front (Question)

Enzyme deficiency in VP

Back (Answer)

Protoporhyrinogen oxidase