PROTEIN SYNTHESIS
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What is Protein Synthesis also known for?
Centril Dogma
Protein Synthesis
The pathway to make proteins from DNA
RNA
A single strand of nucleotide that uses ribose sugars and Uracil instead of thymine
Transcription
Cell copies a DNA sequence into a portable messenger RNA (mRNA) with the help of a RNA polymerase
Messenger RNA (mRNA)
Attaches to ribosomes, it copies DNA’s code and carries genetic info to the ribosomes
Ribosomal RNA (rRNA)
Makes up Ribosomes
Transfer RNA (tRNA)
(Part of Translation) Located at the ribosome transferring amino acids to assemble the growing protein chain
Condon
A genetic code for every 3 nucleotides that makes up one amino acid (20 diff. amino acids are made)
Translation
Cells use the genetic info encoded in the mRNA for tRNA to read mRNA’s instructions and brings the corresponding amino acids to the rRNA for it to produce the protein chain
Mutation
A permanent, structural change in an organism’s DNA sequence
Positives about Mutation!
A source of variation that may provide an advantage
Negatives about Mutation
Protein might no longer function (leading to disease)
Neutral effect of Mutaiton
No change in Protein function
Substitution
One base in the DNA sequence is replaced with a different base
Substitution (significance)
May or May not have a effect on the protein sequence (gambling 😜)
Insertion
An extra base is inserted into the DNA sequence
Insertion (significance)
Condons are altered after this point; proteins has a high chance of being nonfunctional (worse at the start)
Deletion
A base is deleted from the DNA sequence
Deletion (significance)
Condons are altered after this point; proteins has a high chance of being nonfunctional
P53
A tumor suppressor gene that is normally found in human cells
P53 function
Stops/slows down cell division to prevent tumors from forming; recognizes DNA changes; informs cells to fix DNA; triggers apoptosis when cells are damaged
Apoptosis
Cell death
P53 mutations
Is no longer able to send signals to stop division –> leads to tumors forming cancer