Kidney development
No description yet. This curated deck is ready for daily study.
Card preview (11)
Interactions between which 2 structures?
• Ureteric bud 2. Metanephric mesenchyme
What does the ureteric bud induce the nephrogenic mesenchyme to do?
Condense around the bud Undergo a mesenchymal-to-epithelial transition- forming renal epithelium- then renal vesicles
What does the renal vesicle differentiate in to?
The nephron- proximal end: provides local signals for angiogenesis distal ends: fuses with collecting duct by selective apoptosis
What does the uteric bud undergo in order to create 10^6 nephrons?
Branching morphogensis
How many nephrons are there per collecting duct?
6 nephrons
What are the key steps in branching morphogenesis?
• Proliferation and outgrowth of bud tip cells • Arrest in proliferation resulting in flattening • Continued proliferation of lateral tip cells
What is the signal from the mesenchymal cells? And what is the receptor found on the bud?
GDNF signals to the Ret receptor
Where are stem like cells in the kidney found?
Ureteric bud and metanephric mesenchyme
What does Six2 do?
Six2 is a transcription factor that is expressed in nephron stem cells- forms the nephron and all the cells within it
What forms the ureteric bud and metanephric mesenchyme?
Intermediate mesenchyme undergoes a m-to-e transition to form 2 structures: • Nephric duct- forms a lumen and gives rise to the ureteric bud • Nephric cord- gives rise to the metanephric mesenchyme
What happens in attempts to form the definitive kidney?
Pronephric tubules degenerate Mesonephric tubules attracts a blood supply- tubule forms a capsule around a capillary tuft- allowing for blood filtration Mesonephros then largely degenerates Metanephric kidney= finally induced