ANTI-FUNGALS
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Study of fungi
Mycology
TOPICALS: FATTY ACIDS Natural antifungal agent that is part of the innate immune system
Sebum
TOPICALS: FATTY ACIDS 0.1% fungicidal, present in sweat
Propionic Acid
TOPICALS: FATTY ACIDS Fungicide on adhesive tapes
Zinc Proprionate
TOPICALS: FATTY ACIDS Cream-colored granules for superficial dermatomycoses
Sodium caprylate
TOPICALS: FATTY ACIDS Fine white powder fungicide that is unstable in moisture
Zinc caprylate
TOPICALS: FATTY ACIDS From the destructive distillation of castor oil (tangan-tangan; ricinoleic acid)
Undecylenic Acid (10-undecenoic acid, Decenex, Cruex)
TOPICALS: FATTY ACIDS Glyceryl Triacetate Enzactin, Fungacetin
Triacetin
TOPICALS: FATTY ACIDS Only antifungal that cannot penetrate the skin
Benzoic Acid
TOPICALS: FATTY ACIDS Properties of salicylic acid and resorcinol
• Salicylic Acid: antifungal, keratolytic • Resorcinol: antiseptic, keratolytic
TOPICALS: FATTY ACIDS AP-AP Solution
Salicylic Acid + Resorcinol + Benzoic Acid
TOPICALS: FATTY ACIDS Whitfield’s Ointment
Salicylic Acid + Benzoic Acid (+ Base: White Petrolatum) 1:1
TOPICALS Interfere with cell membrane integrity and function in susceptible fungi
Phenol and its derivatives
TOPICALS: PHENOL & DERIVATIVES For superficial tinea infection
Haloprogin Halotex
TOPICALS: PHENOL & DERIVATIVES Substitute for iodoform
Clioquinol Vioform
TOPICALS: PHENOL & DERIVATIVES For jock itch, athlete’s foot, and vaginitis (3%)
Clioquinol Vioform
TOPICALS: PHENOL & DERIVATIVES Second line agent for onychomycosis (ringworm of the nails)
Ciclopirox olamine Loprox
TOPICALS: PHENOL & DERIVATIVES Agent of choice for: * Cutaneous candidiasis * Tinea corporis * Tinea cruris * Tinea pedis * Tinea versicolor
Ciclopirox olamine Loprox
TOPICALS: NUCLEOSIDE For systemic Candida and Cryptococcus spp. infections Antimetabolite
Flucytosine 5-FC, Ancobon
TOPICALS: NUCLEOSIDE Flucytosine is a prodrug that will be converted to ____.
5-Fluorouracil 5-FU
TOPICALS: NUCLEOSIDE Mechanism of action of flucytosine
Inhibition of DNA and protein synthesis
ANTI-FUNGAL ANTIBIOTICS Polyenes are isolated from soil bacterium ____.
Streptomyces
ANTI-FUNGAL ANTIBIOTICS These are isolated from Streptomyces
Polyenes
ANTI-FUNGAL ANTIBIOTICS: POLYENES Natamycin has ____ carbons in its lactone ring.
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