Skeletal system, bone cells and ECM
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Why is the bone classed as an organ?
It’s a collection of tissues that together perform a function. Tissues include: bone, cartilage, blood
Name the six broad functions of the skeletal system and their function.
[SPAM B is FAT] • Support - structure for the body • Protection for internal organs • Assistance in movement - muscles attach to the skeleton • Mineral homeostasis - major calcium and phosphorous reservoir • Blood cell production - produce white and red blood cells • Triglyceride storage - energy reserve
Describe the general structure of bone tissue (and ECM) and the 3 components of ECM
Abundant ECM (extracellular matrix) surrounded by widely separated cells ECM = water, collagen, crystallised mineral salts
What’s an osteoprogenitor?
An unspecialised bone stem cell Undergoes cell division to become oestoblast
What’s an osteoblast?
Immature bone cells surrounded by ECM; become osteocytes Bone formation, initiate calcification Secrete ECM
What’s an osteocyte?
Mature bone cell
Osteoclast
Break down ECM Regulate calcium in blood