Eye
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What includes the Corneoscleral coat of eye
Sclera + cornea
What are the three layers of the eye
Corneoscleral coat Vascular coat Retina
What includes the vascular coat of eye
UVEA Choroid + stroma of ciliary body and iris
What is included in the retinal layer
Retina and epithelium of ciliary body and iris
What are the three chambers of the eye
Anterior chamber Posterior chamber Vitreous chamber
Eye development starts at 22 days with what structure
Optic sulci
An invagination occurs that forms the optic cup… What do the layers of the optic cup make
Inner layer- neural retinal layer Outer layer- retinal pigmented epithelium
Why is the choroid fissure in the eye important
It allows hyaloid vessels to reach the inner chamber of the eye
What does the proximal portion of the hyaloid artery become
Central artery and vein of the retina
What is the key regulatory gene for eye development
PAX6
What does PAX 6 do?
Initiates the formation of a single eye field that is later separated Into two by SHH
What is a coloboma
Cleft in the iris
What are congenital cataracts
Clouding of lens during intrauterine life Can be caused by rubella
What is microphthalmia
When the eye is too small Often from CMV or toxoplasmosis
Anophthalmia
Absence of an eye
Congenital aphakia
Absence of the lens Usually caused by defect in pax 6
Cyclopia
Fusion of the eyes
What are factors that can affect midline structures and cause synophthalmia
Alcohol Mutations in SHH Defects in cholesterol metabolism
Aniridia ?
Absence of the iris Mutations of PAX 6
What is WAGR syndrome
Wilm’s tumor Aniridia Genitourinary abnormalities Retardation (mental)
What is the first layer of the cornea and what is it made of
Corneal epithelium 5 layers of stratified squamous epithelium
What is conjunctivilization of the cornea
Vascularization, appearance of goblet cells, and irregular/unstable epithelium
What is your anterior BM that doesn’t regenerate in your cornea
Bowman’s membrane
What is the third layer of the cornea and what is it made of
Corneal stroma Collagen fibrils