Lecture 14
No description yet. This curated deck is ready for daily study.
Card preview (7)
Classification of Genetic Disorders
• Single gene • Multifactorial diseases • Chromosome disorders • Mitochondrial disorders • Somatic mutations
Autosomnal dominance
Autosomnal recessive
Cystic fibrosis Recessive allele has no effect on organism’s phenotype if only 1 allele is present in genome
Dominant allele
• Determines phenotype when 1 copy present in genome
X linked inheritence
• Incidence much higher in male than female • Transmitted from man to all daughters • Gene never transmitted from father to son • Son always inherits X chromosome from mother
Multifactorial Inheritence
COmbination of small inherited variations in genes, environmental Heart disease, diabetes, cancers
Mitochondrial Inheritance
• Defect in oxidative phosphorylation • ## Severe