Carbohydrates
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The simplest carbohydrate
Glycol aldehyde
Most common nunreducing sugar
Sucrose
Pancreas Exocrine: Endocrine:
Enzymes (AMS, LPS) Hormones (Insulin, glucagon, somatostatin)
Hyperglycemic Hormones “GAG CHET”
Glucagon ACTH GH Cortisol Human Placental Lactogen Epinephrine Thyroxine
Hyperglycemia (≥126 mg/dL) Electrolyte Imbalance: Increased: Decreased:
Potassium Sodium, Bicarbonate
Hypoglycemia = Symptoms = Diagnostic
50-55 mg/dL ≤50 mg/dL
Whipple’s triad (Hypoglycemia)
Low blood glucose concentration Typical symptoms Symptoms alleviated by glucose administration
Ratio of BHA to AA in severe DM (Normal = 1:1)
6:1
IDDM
Type 1 DM
Juvenile Onset
Type 1 DM
Brittle
Type 1 DM
Ketosis-prone
Type 1 DM
80-90% reduction of beta-cells
Symptomatic Type 1 DM
HLA-DR3 and DR4
Type 1 DM
(+) Glutamic acid decarboxylase (GAD65)
Type 1 DM
(+) Insulin autoantibodies
Type 1 DM
(+) Microalbuminuria: 50-200 mg/24 hours = Diabetic nephropathy
Type 1 DM
(-) C-peptide
Type 1 DM
Complications of Type I DM
Microvascular disorders: Nephropathy Neuropathy Retinopathy
NIDDM
Type 2
Adult type/Maturity Onset
Type 2
Stable
Type 2
Ketosis-resistant
Type 2
Receptor-deficient
Type 2