Processes to do w bones (calcification, remodelling)
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What is calcification?
Mineral salts and ions are deposited in a framework formed by collagen fibres to crystallise and harden the tissue. Initiated by osteoblasts.
What materials contribute to bone hardness and what allows flexibility in bones?
Hardness: crystallised mineral salts Flexibility - collagen fibres
What is bone remodelling?
The ongoing replacement of old bone tissue with new bone tissue
What is bone deposition and bone resorption?
Bone deposition – addition of minerals and collagen fibres by osteoblasts Bone resorption – removal of minerals and collagen fibres by osteoclasts
Osteoprogenitor
Unspecialised cells Undergo cell division Develop into osteoblasts
Osteoblasts
Bone building cells Bone deposition/calcification Forms bone ECM/collagen fibres
Osteoclasts
Bone resorption (destruction of old bone ECM)
Osteocytes
Mature bone cells, maintain daily metabolism