D3.2 Inheritance
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What are haploid gametes?
Gametes with 1 copy of each chromosome, produced by meiosis; fuse to form diploid zygote.
What is a homologous chromosome?
Same size, banding, centromere, genes at same loci; may have different alleles.
Define allele, genotype, phenotype.
Allele = version of a gene; Genotype = allele combination; Phenotype = observable trait.
Homozygous vs heterozygous vs hemizygous?
Homozygous = same alleles; Heterozygous = different alleles; Hemizygous = only 1 allele (e.g., male X-linked).
P, F1, F2 generations?
P = pure-breeding parents; F1 = offspring of P; F2 = offspring of F1 self-cross.
How to do a Punnett square?
Assign alleles (dominant uppercase), write gametes, fill grid, determine genotypes & phenotypes.
Mono- vs dihybrid cross?
Mono = 1 gene, dihybrid = 2 genes (independent assortment).
Dominant vs recessive allele effects?
Dominant expressed in homozygous/heterozygous; recessive only in homozygous.
Example?
Mouse coat: B = black (dominant), b = light (recessive).
PKU inheritance & cause?
Autosomal recessive; mutation in PAH gene → phenylalanine accumulates → brain damage.
Haemophilia inheritance?
X-linked recessive; males affected, females carriers; defective clotting factor gene on X.
Multiple alleles?
More than 2 alleles in gene pool; individual inherits 2.
Incomplete dominance?
Heterozygote shows intermediate trait (e.g., Mirabilis jalapa flowers: red × white → pink).
ABO blood group?
IA & IB codominant, i recessive.
How is human sex determined?
XX = female, XY = male; sperm determines sex.
X-linked inheritance rules?
Affected father → all daughters affected. Affected mother → sons affected, daughters may be carriers.
Continuous vs discrete traits?
Continuous = polygenic/environment (e.g., skin color); Discrete = single gene (e.g., ABO).
Phenotypic plasticity?
Trait changes via gene expression in response to environment (e.g., snail shell shape).
Box-and-whisker plot?
Shows min, max, median, Q1, Q3, outliers (1.5 × IQR).