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Multipotent haematopoietic stem and progenitor cells (HSPCs) are the source for _.
all blood cell types
The bone marrow stem cell niche in which the HSPCs are maintained is known to be _.
vital for their maintenance
_ in which the HSPCs are maintained is known to be vital for their maintenance.
The bone marrow stem cell niche
Endosteal Niche: This niche is located _. It primarily involves interactions between . The endosteal niche is crucial for maintaining the quiescence () of HSCs and for regulating their _
near the inner surface of the bone (endosteum) _ osteoblasts (bone-forming cells) and hematopoietic stem cells (HSCs). _ a non-dividing state _ differentiation into various types of blood cells. _
Perivascular Niche: This niche is found _. It is rich in cells like _. The perivascular niche supports the _ and is key for _.
surrounding the blood vessels within the bone marrow and other tissues _ endothelial cells (which line blood vessels) and mesenchymal stem cells _ proliferation and differentiation of HSCs _ the mobilization of these cells into the bloodstream