Large animal models
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Name advantages of using large animals as models
• outbred • repeated blood samples possible • tissue biopsies • longer life-span • similar size to that of humans
Name disadvantages of large animal models
• outbred • expensive • limited number of animals for practical and economical reasons • handling can be cumbersome
Where can you sample blood from pigs?
• jugular vein • ear vein • mammary vein • retroorbital plexus
Name three different pig/swine kinds
• Yorkshire (pointy ears standing up) • Hampshire (belt) • landrace (ears hang down)
Why do you use minipigs for long-term studies?
They don’t grow that big
What are Göttingen minipigs bred from?
minnesota minipig + vietnamese pig + landrace
What are the 3 As in pig research?
• Acclimatisation • Analgesia and Anaesthesia • Aseptic procedures
What are dogs used for in research?
• test new pharmaceuticals • toxicity - non-rodent model • surgery - transplantation • insulin 1920s breakthrough • Gi tract • new vaccines for dogs • dentistry
Where are cat models used?
• CNS • neurology • opthalmology
Research on primates
• HIV • transplantation • ophtalmology • PET
Research areas that use rabbits
• orthopedics • osseointegration • ophtalmology • antibody production