L16 - drug solubility & dissolution rate 1

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Total cards: 24•Content version: v3•Public deck•Updated: 8/1/2026

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Front (Question)

drugs function as what in body?

Back (Answer)

solution (drugs have to be dissolved before being absorbed)

Front (Question)

what tends to happen to poorly soluble drugs in the GI tract?

Back (Answer)

eliminated in gi tract before dissolution

Front (Question)

what is bioavailability?

Back (Answer)

rate and extent of absorption

Front (Question)

what happens if there is low aqueous solubility?

Back (Answer)

poor BA

Front (Question)

define solution

Back (Answer)

molecular dispersion formed by 2+ components which form a “one phase” homogenous system. solute + solvent = solution

Front (Question)

deine miscibility

Back (Answer)

solution can be solid, liquid or gas

Front (Question)

define solvent

Back (Answer)

compound that determines phase of solution

Front (Question)

solute

Back (Answer)

other components of solution dispersed as molecules/ions throughout solvent, dissolved in the solvent

Front (Question)

saturated solutions

Back (Answer)

solvent is in equilibrium with solid phase (solute), no more solute will dissolve in it

#10

Front (Question)

define solubility (quant terms)

Back (Answer)

concentration of solute in a saturated solution at a certain temp (max mass of solute that will dissolve in given ass of solvent at a certain temp)

#11

Front (Question)

define solubility (qual way)

Back (Answer)

spontaneous interaction of 2+ substances to form a homogenous molecular dispersion

#12

Front (Question)

unsaturated or sub saturated solution

Back (Answer)

conc of dissolved solute is below necessary conc for complete saturation at definite temp

#13

Front (Question)

supersaturated solution

Back (Answer)

contains more of the dissolved solute that it would normally contain at a definite temp (dissolution in large amounts at higher temp)

#14

Front (Question)

what amount of solute is not consisted soluble at all?

Back (Answer)

1mg/ml

#15

Front (Question)

ppm

Back (Answer)

parts per million

#16

Front (Question)

ppb

Back (Answer)

parts per billion

#17

Front (Question)

% w/w

Back (Answer)

number of grams of solute in 100g of total solution

#18

Front (Question)

% w/v

Back (Answer)

number of grams of solute in 100ml of solution

#19

Front (Question)

molarity

Back (Answer)

moles per LITRE

#20

Front (Question)

molality

Back (Answer)

number of moles of compound associated with 1kg of solvent

#21

Front (Question)

normality

Back (Answer)

number of protons in a compound

#22

Front (Question)

mole fraction

Back (Answer)

the known moles of the known compound over the total moles of the system

#23

Front (Question)

class I drugs

Back (Answer)

high permeability, high solubility

#24

Front (Question)

class 2 drugs

Back (Answer)

low solubility, high permeability