Burkitt's Lymphoma (Nucleus)
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Where is the perinuclear space?
B/t INM and ONM, and is often continuous w/ some RER cisternae
What is the number of nuclear pores (10-30% of surface area) directly related to?
Transcriptional activity
Is euchromatin condensed or dispersed? transcriptionally active or inactive? Heterochromatin active/inactive, condensed/dispersed?
Euchromatin = dispersed and transcriptionally active Heterochromatin = highly condensed and transcriptionally inactive
Is constitutive heterochromatin always condensed or can be dispersed as needed? Facultative condensed/dispersed as needed?
constitutive = always condensed facultative = dispersed as needed
True or False, 46 threads that make up a chromosome are commonly seen in a cell’s nucleus?
False; Only seen during nuclear division
What is the term when a gametic cell divides? When a somatic cell divides?
Gametic cell division = meiosis Somatic division = mitosis
What are the proteins called that control the cell cycle?
Cyclin-dependent kinases, which are controlled by cyclins, which are controlled by mitogens
What stage of interphase do mose of our cells live their lives?
G1 (growth and normal metabolic roles) *longest phase
Is the cell life cycle/transition between phases unregulated, slightly regulated, or highly regulated?
Highly regulated
Which phase is the slowest phase in Mitosis?
Prophase
During prophase, what are are chromatids held together at centromere by?
2 protein kinetochores
What are the 3 kinds of microtubules that make up the spindle apparatus?
Astral microtubules (star like at each end) Kinetochore (from centrosome to kinetochore) Polar microtubules (from centrosome to other centrosome)
What does “ras” code for? What does “erb” code for?
ras codes for a mutant G-protein that binds GTP but can’t cleave to GDP, so it stays on Erb codes for a damaged epidermal growth factor so it does not require the growth factor to function, so it’s on all the time
Burkitt’s lymphoma is a disease caused from?
Failure in nucleus. Some DNA is corrupted by translocation (chromosomes 8 & 14) and looses control of cell division