Endocrine: Adrenal Gland
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located above the kidney, shaped like pyramids Maintain BP, Na, K, Glucose hemeostasis
Adrenal Gland
treated with exogenous hormone replacement
Hypofunction
Treated with supressive drugs and surgery
Hyperfunction
Adrenal composed of 2 Glands
Adrenal Cortex (OUTER) Adrenal Medulla (INNER)
Arise from mesenchymal cells with 3 zone layer
Adrenal Cortex
3 zone layer of Adrenal Cortex
• Glomerulosa (G-cell) • Fasciculata (F-cell) • Reticularis (R-cell)
Mineralocorticoid Aldosterone Salt
Glomerulosa (G-cell) (10%
Glucocorticoids Glucose Cortisol
Fasciculata (F-cell) (75%)
DHEAS Sex steroids
Reticularis (R-cell) (10%)
stimulate production of Epinephrine
Glucocorticoids
arise from neural crest
Adrenal Medulla
Major Hormones involved in Hypothalamic Pituitary Axis
ACTH and Angiotensin CRH Cortisol
Major Substrate precursor for Adrenal Cortex
Cholesterol
Cholesterol is derived from (2)
• from LDL • from Acetyl CoA
Zonal Glomerulosa Urinary Metabolite
17-hydroxycorticosteroids
Zonal Reticularis Urinary Metabolite
17-ketosteroids