Krebs cycle

1.The citrate synthase enzyme fuses Acetyle coa and oxaloaceacetate together 2.If there is too much ATP , citrate, succonylcoa & NADH it will inhibit the enzyme to making it 3.ADP stimulates the enzyme making it go through the kreb cycle to produce more ATP.

• The citrate to isocitrate and the still the same 6 in citrate and 6 in isocitrate but this a isomerisation reaction what is reverisable.

• NAD + into NADH 2.Isocitrate goes to alpha kentogultarate D.H and it loses one carbon to CO2 through decarboxlycation 3.There are binding site, ATP binding and inhibits it and Ca+ ions and ADP stimulate to make ATP.

1.Alpha kentogulatarate goes to Alpha kentogulatarate enzyme and it loses one carbon through decarboxylation to Co2 (Now 4 carbons) 2.NAD+ into NADH 3.Succinyl coa and NADH inhibits the enzymes to making stop production of it. 4. Calcium stimulates the enzyme to speed up ATP production

• CoA is added then removed 2.GDP- GTP-ADP (gains phosphate)-ATP 3.ATP blocks the GTP so the GTP-GDP 4.Succinyl coa itno sucinate

1.FAD- FADH2 2.Reverisble reaction 3.Can lead to pheochromocytotoma which os a tumour in the adernal medulla

• H20 is added to when it goes from fumarase to malate • Deficinicy in this enzyme leads to a tumour leiomas- benign in smooth muscles

• NAD- NADH • Reversible reaction