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Wnt signalling

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Total cards: 8•Content version: v4•Public deck•Updated: 8/1/2026

Card preview (8)

#1
Front (Question)

What is the Hg, Wg and En autoregulatory loop?

Back (Answer)

Wg and Hh maintain each others expression in an autoregulatory loop Hh upregulates Wg Wg upregulates En En downregulates Hh

#2
Front (Question)

What are the 2 modifications of the Wnt protein before its secretion?

Back (Answer)

• Palmitoylation 2. Palmitoleic acid addition

#3
Front (Question)

Which drosophila genes are involved in the reception and transmission of the Wnt signal to the nucleus?

Back (Answer)

Frizzled Dishevelled Groucho

#4
Front (Question)

Example of a Wnt inhibitor

Back (Answer)

Dickkopf1 (Dkk1)

#5
Front (Question)

What does loss of axin1 in zebrafish embryos cause?

Back (Answer)

Posteriorisation of the anterior brain- loss of eyes

#6
Front (Question)

What does Wnt do in intestinal crypts?

Back (Answer)

Wnt is required for the maintenance of stem cells Wnt expressed by the stroma- below the crypts

#7
Front (Question)

Examples of 3 diseases associated with Wnt signalling

Back (Answer)

• Tetra amelia syndrome- absence of limbs • Increased bone density (insensitive to DKK) • Tooth agenesis (missing teeth)

#8
Front (Question)

What does the loss of the APC gene cause? And how does this link to adenomatous polyposis?

Back (Answer)

Loss of the APC gene can cause ectopic Wnt signalling Adenomatous polyposis (heterozygous for APC gene)- polyps caused by random loss of remaining WT copy of APC gene- resulting in activation of Wnt- proliferation of cells forming polyps