Week 3
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In general terms, what is the First stage of Aerobic ATP production ?
Generation of Acetyl- CoA
In general terms, what is the Second stage of Aerobic ATP production ?
Oxidation of Acetyl CoA (Krebs Cycle)
In general terms, what is the Third stage of Aerobic ATP production ?
Oxidation Phosphorylation (ATP production in ETC)
Where is Acetyl CoA generated?
Mitochondria
What is the primary function of the Krebs cycle
Produce electron carriers; NADH, FADH, H+
How many turns of the Krebs Cycle result from 1 Glucose Molecule ?
2
What is the first step of the Krebs cycle?
Removal of carbon from Pyruvate to form Acetyl-CoA
What enzyme is responsible for the transformation of Pyruvate into Acetyl-CoA ?
Pyruvate Dehydrogenase
What is the first oxidation reduction reaction of the Krebs cycle and what results from this?
Isocitrate > alpha-Ketoglutarate (enzyme = isocitrate dehydrogenase) Results in : NADH and CO2
What is the rate limiting enzyme of the Krebs cycle
Isocitrate Dehydrogenase
What is the second oxidation reduction reaction of the Krebs cycle and what results from this?
Alpha-ketoglutarate > Succinyl-CoA (enzyme = alpha-ketoglutarate Dehydrogenase) Results in; NADH &CO2
In the Krebs cycle, What does the reaction of Succinyl-CoA > Succinate produce ?
GDP > GTP > ADP > ATP
What reaction produces FADH in the Krebs cycle ?
Succinate > Fumarate
What is the last step in the Krebs Cycle and what does it result in?
Malate > Oxaloacetate Results in; NADH
What stimulates the Krebs cycle
ADP & Calcium
What inhibits the Krebs Cycle?
ATP negative feedback
What are the requirements of Aerobic Energy generation?
Acetyl-CoA Oxygen Efficient waste removal (CO2)
2 physiological factors influencing VO2 Max
Ability to deliver O2 to the muscle Ability of muscles to use O2 and produce ATP aerobically
Name the 6 factors contributing to EPOC
Resynthesis of PC in the muscles Lactate conversion to Glucose Restoration of muscle and blood O2 stores Elevated body temp. Post-exercise elevation of HR and RR Elevated hormones
Define Lactate Threshold
Point at which blood lactate will raise systematically during incremental exercise
How will lactate threshold be different in trained subjects vs untrained ?
It will occur at a higher percent of the individuals VO2 max