LECTURE 23 DISEASE
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TUBERCULOSIS is also known as
mycobacterium tuberculosis
how long does it take to grow
2 weeks to form a colony
who won the nobel prize for tubeculosis
Robert Koch in 1882
how is tuberculosis is transmitted
person to person sopread
hwo is tb a professional pathogen
it is not supposed to be in the body so if it is, it causes diseases
Steps to get infected by TB
host inhales immune cells recruited, phagocytose bacteria bacteria get to lung tissue bacteria survive, replicate
bacteria is replicated in
ghon complex (calcified)
characteristics of tb active disease
months to decades once immune cells faul to contain replication it disseminates into lungs, bloodstream and other organs
who are most susceptible to tubeculosius
homeless, elderly, malnourished, prisons
How is tb detected
PPD Chest X-ray Blood culture DNA probes
How effeicient is BCG
more efficient in children than adult. 950-80 % efficient)
what drug is used to treat tb
streptomycin
which form of tuberculosis is tough to treat, resistant to multiple drigs and have inadequate therapy
MDR-TB
Leprosy is also known as
Hansen’s disease (Mycobacterium leprae)
how is leprosy contacted
prolonged close contact, nasal secretions
incubation period of leprosy
3-5 years (up to 20 years)
what type of pathogen is leprosy
obligate intracellular pathogen ( must get into the cell)
where does leprosy invade
invade nerve or skin cells
describe tuberculoid keprosy
hypersensitivity reaction, skin lesions and dmaage to nerves, skin
which type of leprosy invade skin schwann cells covering nerves
lepromatous leprosy
rabies is also known as
rhabdovirus (virus)