LIPIDS & LIPOPROTEINS
No description yet. This curated deck is ready for daily study.
Card preview (24)
Primary source of fule, provide stability to cell membrane and allow for transmembrane transport
Lipids
Lipids are insoluble in blood and water, but soluble in ___
organic solvents like chloroform and ether
Most abundant lipids derived from phosphatidic acid
Phospholipid (Conjugated Lipid)
Phospholipid is produced from the conjugation of
two fatty acids & phosphorylated glycerol
Reference Value of Phospholipid
150-380 mg/dL Serum
Only phospholipid in membranes that is not derived from glycerol but from an amino alcohol called sphingosine
Sphingomyelin
Sphingomyelinase accumulates in the liver and spleen of patients suffering from what disease
Niemann-Pick disease Lipid storage disorder
Mature lung function correlates strongly with a Lecithin/Sphingomyelinase ratio of
less than or equal to 2
Unsaturated steroid alcohol containing four rings, has a single C-H side chain tail similar to fatty acid
Cholesterol
Where is Cholesterol synthesized
Liver
Reference value of Cholesterol
< 200 mg/dL
Borderline Cholesterol
200-239 mg/dL
High Cholesterol
> or = 240 mg/dL
Cholesterol is the precursor of five major classes of steroids
• Progestins • Glucocorticoids • Mineralocorticoids • Androgens • Estrogens
Cholesterol bound to fatty acid Found in plasma and serum
Cholesterol Ester 70% of cholesterol
Cholesterol bound to fatty acid Found in plasma and serum
Cholesterol Ester 70% of cholesterol
Cholesterol ester undergoes esterification by what enzyme
LCAT Lecithin-Cholesterol Acyltransferase
LCAT promotes the transfer of fatty acid from lecithin & cholesterol and forms
Lysolecithin Cholesterol Ester
Activator of LCAT:
Apo-1
A polar nonesterified alcohol Found in Plasma, serum and RBCs
Free Cholesterol 30% of Cholesterol
A polar nonesterified alcohol Found in Plasma, serum and RBCs
Free Cholesterol 30% of Cholesterol
Patient preparation for Cholesterol testing
Patient should be in their usual diet Neither gaining nor losing weight
End product: Choestadienyl Monosulfonic Acid Green color Chemical Method
Liebermann Burchardt Reaction
End product: Cholestadienyl Disulfonic Acid Red color Chemical Method
Salkowski Reaction