Endomembrane System

1- adding carbs to glycoprotein 2- folding of polypeptides 3- fixing misfolded proteins 4- assembly of multimeric proteins

1- drug detoxification 2- carb metabolism 3- calcium storage 4- steroid biosynthesis

NADPH dependent process of adding OH groups to drugs to make them easier to excrete

protien catalyst of hydroxylation

converts glucose-6-phosphate to free glucose in carb metabolism

commited step in cholesterol biosynthesis

transfer phospholipids from the cytoplasm to the ER lumen

move phospholipids to designated organelles (mitochondria, chloroplast, or peroxisomes)

further processing, sorting, and packaging of membrane lipids

Addition of side chains to the N of asparagine or OH of serine, threonine, or tyrosine to create a glycoprotein

2x N-acetylglucosamine, 9x mannose, 3x glucose. Beginning side chain of all glycoproteins until trimmed and modified in the ER lumen

addition of oligosaccharide as the polypeptide is being formed

form a protein complex to promote proper folding and disulfide bond formation of glycoproteins

further processing of glycoproteins withing the golgi, involving removal and addition of units to the core oligosaccharide

targets the protein to a transport vesicle that will take it to the right location

uptake of completed polypeptides with targeting signals into their designated organelle (after translation in cytoplasm)

polypeptide is brought into the ER as synthesis occurs (stays in endomembrane system)

polypeptides destined for ER have an ER signal sequence that direct the mRNA to the RER

protein containing an ER signal sequence

mediates the contact of the ribosome to the ER

structure of ER membrane responsible for translocation of polypeptides across the ER membrane

protien tag that keeps them in the ER

tag on proteins that return from the golgi to the ER

tag that sends lysosomal proteins to lysosomes