SYNTHETIC ANTIBACTERIALS
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Synthetic antibacterial agents are antibiotics. True or False
False Antibiotics are from natural origin.
QUINOLONES Quinolones are patterned after ____, which is a ____ derivative.
• Nalidixic acid • Naphthyridine
QUINOLONES Prototype quinolone
Nalidixic Acid
QUINOLONES Nalidixic Acid Identify the isosteric heterocyclic grouping.
Napthyridines
QUINOLONES Enoxacin Identify the isosteric heterocyclic grouping.
Napthyridines
QUINOLONES Cinoxacin Identify the isosteric heterocyclic grouping.
Cinnolines
QUINOLONES Norfloxacin Identify the isosteric heterocyclic grouping.
Quinolones/Fluoroquinolones
QUINOLONES Ciprofloxacin Identify the isosteric heterocyclic grouping.
Quinolones/Fluoroquinolones
QUINOLONES Ofloxacin Identify the isosteric heterocyclic grouping.
Quinolones/Fluoroquinolones
QUINOLONES Lomefloxacin Identify the isosteric heterocyclic grouping.
Quinolones/Fluoroquinolones
QUINOLONES Sparfloxacin Identify the isosteric heterocyclic grouping.
Quinolones/Fluoroquinolones
QUINOLONES Mechanism of action of quinolones
• DNA Topoisomerase IV inhibitor • DNA gyrase inhibitor (TP II) -> Supercoiling -> -Cidal
QUINOLONES Nalidixic Acid Identify the generation.
1st
QUINOLONES Cinoxacin Identify the generation.
1st
QUINOLONES Norfloxacin Identify the generation.
2nd
QUINOLONES Ciprofloxacin Identify the generation.
2nd
QUINOLONES Enoxacin Identify the generation.
2nd
QUINOLONES Ofloxacin Identify the generation.
2nd
QUINOLONES Levofloxacin Identify the generation.
3rd
QUINOLONES Sparfloxacin Identify the generation.
3rd
QUINOLONES Moxifloxacin Identify the generation.
3rd
QUINOLONES Gemifloxacin Identify the generation.
3rd
QUINOLONES Trovafloxacin Identify the generation.
4th
QUINOLONES • Gram (-) • Not Pseudomonas species Identify the generation based on the spectrum described.
1st