CORONARY HEART DISEASE
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WHAT IS CORONARY HEART DISEASE
ATHEROMA FORMATION IN THE CORONARY ARTERIES
WHAT PROPORTION OF MYOCARDIAL ISCHAEMIA IS CAUSED BY CHD
90%
NARROWING OD THE LUMEN BY WHAT PERCENT IS ENOUGH TO PRODUCE SYMPTOMS OF CHD
50%
WHAT DISEASE IS THE MOST COMMON CAUSE OF PREMATURE DEATH
CHD
WHAT ARE THE MAHOR UNMODIFIABLE RISK FACTORS FOR CHD
AGE GENETICS AND SEX
WHAT ARE THE MODIFIABLE RISK FACTORS FOR CHD
DYSLIPADEMIA SMOKING HYPERTENSION DIABETES OBESITY PGYSIOCAL INACIVITY METABOLIC SYNDROME
WHY IS AGE A RISK FOR CHD
CELLULAR SENESCENCE (ABILITY TO REPAIR ENDOLTHELIAL DAMAGE DECLINES) TIME - OPPORTUNITY FOR PLAQUE MATURATION
WHAT FAMILIAL TRENDS PLAY A ROLE IN CHD
DIABETES AND HTN
WHICH PEOPLE HAVE A HIGHER INCIDENCE OD CHD
MEN AND POST MENOPAUSAL WOMEN
WHAT IS DYSLIPADEMIA
ABNORMAL CONCENTRATIONS OF SERUM LIPOPROTEINS AND TRIGLYCERIDES
WHAT DO LIPOPROTEINS DO
TRANSPORT LIPIDS IN CIRCULATION
LIPOPROTEINS VARY IN THEIR ……….. RATIO
PROTEIN TO LIPID RATIO
WHICH DENSITY LIPOPROTEIN IS BAD
LOW DENSITY
WHAT DOES LDL DO
DELIVER CHOLESTEROL FROM LIPID STORES TO PERIPHERAL TISSUES
WHAT DOES HDL DO
TRANSPORT CHOLESTEROL FROM PERIPHERAL TISSUES TO THE LIVER FOR EXCRETION
WHAT MECHANISMS FROM SMOKING CONTRIBUTES TO CHD
TOXIC CHEMICALS CAUSE CELLULAR DAMAGE NICOTINE INCREASES VASOMOTOR TONE SMOKING INCREASES PLATELET AGGREGATION
WHAT BP MEASUREMENT INDICATES HTN
140/90
WHAT IS HYPERTENSION
CONSISTENT ELEVATION OF SYSTEMIC ARTERIAL BP
HOW IS INSULIN RESISTANCE RELATED TO CHD
IT IS ASSOC WITH A PROINFLAMMATORY STATE, CONTRIBUTING TO ENDOTHELIAL INJURY
WHAT IS METABOLIC SYNDROME
HAVING THREE OF 5 OF VISCERAL PBESITY INSULIN RESISTANCE, LOW HDL CHOLESTERL, HIGH TRIGLYCERIDES, HTN, INCERASING RISK OF CHD BY 2-3X
PLAQUES HAVE A : …… CAP, ….. MATRIX, AND WHAT 4 TYPES OF CELLS
FIBROUS CAP CONNECTIVE TISSUE MATRIX MACROPHAGES, FOAM CELLS, SMOOTH MM CELLS, AND LYMPHOCYTES
WHAT DOES PLAQUE DEVELOPMENT BEGIN WITH
ENDOTHELIAL DAMAGE FROM A RISK FACTOR
WHAT IS ANGINA
CHEST PAIN CAUSED BY MYOCARIDAL ISCHAEMIA
WHY IS STABLE ANGINA
CHEST PAIN CAUSED BY GRADUAL AND INCOMPLETE NARROWING OF THE CORONARY ARTERY LUMEN