Parkinsons
暂无描述。系统推荐的高质量记忆内容，适合每天坚持背诵学习。
卡片预览 (24 张)
What does it do?
Carbidopa Inhibitor of AAD
What the give away that makes it an inhibitor
Talcapone COMT I Nitro group with catechol system
Propargel group MAO I irreversible
Its a potent?
Dopamine agonist Emetic Dopamine in locked conformation Previagra Apomorphine
In parkinsons there are two receptors in the striatum? Which one is decreased which one is increased?
D1-Excitatory decreased D2- Inhibitory increased
Direct pathway?
D1
Indirect pathway
D2
tyrosine, tyrosine epoxide DA semiquinone and DA quinone are all?
Compounds indicated in neuronal cell death
D1, 5 receptor increases levels of?
cAMP
D2-4 receptor decrease levels of?
cAMP
Tyrosine is converted into _____ then in the presence of _____ is coverted to?
L-dopa (BBB+) MAO Dopamine (BBB-)
How does L-dopa cross the BBB?
It is actively transported and the presence of both the Amino and Carboxylic acid group forms a zwitter ion and cause less unionizable things
MPPP —-> ____ —- MPDP—>MPP Causing?
Nigrostriatal cell death
Apomorphine locks dopamine in what conformation which is?
Locked into trans alpha rotamer which is favorable to the receptor
L-dopa is used in combination with? Which is?
Carbidopa Aromatic AA Decarboxylase Inhibitor and COMPT
Adverse effects of combination L-dopa and carbidopa therapy?
Dose related dyskinesia (Impairement of voluntary movement) Pathological gambling CNS effects simialr to Schizo
Tolcapone and Entacapone are?
Compt I
Entacapone has a?
Short T1/2 and should be taken with every dose of L-dopa
Amantadine is a?
DA releaser ClogP = 2.0
MAO-B inhibitors have a? bond
Ctriple bond CH Irreversible inhibitor of MAO-B
Rasagiline has?
Fewer adverse effects compared to L-deprenyl (Selegiline)
Sofinamide is a?
Reersible and selective MAO-B I
DA receptor agonists they all have?
Can lower required dose of l-dopa Locked confomer of DA S-enatiomer has post synaptic D2 antagonism
Anticholinergics do what for parkinsons?
Help reduce drooling and tremors