5HT And NE
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What are the two types of monoamines?
Indolamines and catecholamines
Out of dopamine, norepinephrine, epinephrine, and serotonin, which of the above are indolamines?
Serotonin
What is the rate limiting enzyme on the path from L-tyrosine to Epinephrine?
Tyrosine hydroxylase (TH)
What are the enzymes that inactivate catecholamines?
MAO and COMT
What is MAO-A selective for?
NE and serotonin
What is MAO-B for?
It acts on dopamine and broad spectrum of phenylethylamines
Norepinephrine deficiency syndrome common symptoms:
• impaired attention • depressed mood • psychomotor retrardation
Serotonin containing neuronal cell bodies are mainly restricted to discrete clusters of cells located along the midline of the brain stem - _________
The raphe nuclei
5-HT 1A is located where? what does it cause?
Somatodendritic auto receptors and postsynaptic ; decrease in firing and decrease in 5HT release
5-HT 1D is located where? What does it do?
Terminal auto receptors ; inhibit release of neurotransmitters
What are the serotonin receptors for mood?
Postsynaptic beta 1 receptor
What is the function of 5HT 2A?
• stimulation of phospholipase C • closing of K+ channels
What serotonin receptors are involved in anxiety and panic?
5HT-2A and 5HT-2C
What serotonin receptors are involved in appetite and eating behavior?
5HT-3
What serotonin receptors are involved in appetite and GI motility?
5HT-3 and 5HT-4
What serotonin receptor is involved in sleep?
5HT-2A
What serotonin receptor is involved in the vomit center?
5HT-3
What are the symptoms of serotonin deficiency syndrome?
• depressed mood • anxiety • panic -phobia • anxiety • obsessions and compulsions • food craving; bulimia
What happens when the alpha 2 hetero receptor is activated on the serotonin neuron?
It inhibits 5HT and NE
What is the alpha 1 receptor coupled to?
Gq
Alpha 1 ______ 5HT production while alpha 2 ______ it
Increases; inhibits
What was the original purpose for MAO inhibitors?
To treat tuberculosis
What was the first drug discovered to treat depression?
MAO inhibitors
the original MAO inhibitors were __________ and ___________
Non-selective and irreversible