Pharmacology

Refers to a group name i.e. penicillin

a New Zealand Crown entity that decides on behalf of the DHB’s which medicines and pharmaceutical products are subsidised for use in the community and public hospitals

the administration of drugs by ay route other than mouth

a large group of proteins that are molecule targets for drugs and lignads

the study of how a drug is altered during the process of absorption, distribution, metabolism, and exception

biological molecule that catalyses a chemical reaction or causes a chemical change in another substance

the major site for absorption of orally administered drugs

orally administered drugs pass from the intestine to the liver before reaching the systemic circulation resulting in a proportion of the medication being metabolised by the liver before it reaches the bloodstream

the enzymatic breakdown of a drug to a metabolite, that is typically less biological active and more water soluble (making it easier to be exerted in the urine)

a drug that binds to and activates the receptor, producing the same response as the indigenous ligand

a drug that binds to the receptor and blocks the access to the endogenous ligand, thus diminishing the normal response

unintended and undesirable response to a drug

predictable, unintended, and undesirable response to a drug

unpredictable, unintended, and undesirable response to a drug

the disintegration of a cell by rapture of the cell wall or membrane

a drug that is converted to its active form after absorption

complex, mesh-like structure that in most bacteria is essential for maintenance of cell shape and structural integrity

the situation in which the rate of a drug administered equals the rate of elimination and the plasma concentration remains constant

the time taken for the blood or plasma concentration of a drug to fall by 50%

the study of genetic differences that can alter an individual’s response to a drug

the study of the interaction between a drug and its molecular target, and the physiological response. What the drug does to the body - usually described as the mechanism of action

a cause for metabolic drug interactions, usually arises from an increase synthesis of more of the enzyme protein leading to an increase in drug metabolism

the New Zealand Medicines and Medical Devices Safety Authority, is the medical regulatory body run by the NZ MOH

the volume of blood plasma cleared of creatinine per unit time. It is a rapid and cost-effective method for the measurement of renal function