Cell Interactions 2
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Are glycines small or large ?
Small
What happens to protolines ?
They become modified so that we can have hydrogen bonds
What could collagen be referred to as ?
A single protein or a triple helix, but must be clear what type of collagen we’re talking about.
What type of structure is a triple helix of collagen ?
A quantinary structure
What will happen to triple helices in order for them to become fibrils ?
They get cross linked
Every collagen is how many proteins ?
One protein
Where do we want to form collagen fibrils ?
Outside the cells
How do we make sure we dont form fibrils inside the cell ?
We must remain unfolded until we reach the final destination
When will acid hydrolase only work ?
Only works at low ph because it wont fold properly otherwise
Where is low ph located ?
Locked in the lysosome
When do we fold collagen correctly ?
Outside the cell
Where do we have non helical regions ?
Both ends of the N and C termini
Why do we cleave the chunky stuff off the N and C termini ?
So that collagen will assemble and eventually form into fibrils
Where will the collagen peptidase only work ?
Outside the cell
The enzyme procallgen will only work when ?
Outside the cell
Where does glycosilation take place ?
In the golgi
When we make it protein where will it be sent ?
Sent to the secretion pathway and then sent to the sugar ?