module 4
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nutrients with antioxidant properties:
-vitamin E -vitamin C -vitamin A -selenium
unstable atoms in the body
free radicals
what causes free radicals:
-metabolic processes -electron transport chain -immune system -environmental factors
carotenodermia
-orange discoloration of skin due to over consumption of beta-carotene
vitamin A role:
-antioxidant; scavenges free radicals & protects LDLs from oxidation -essential for healthy vision -cell differentiation process -sperm production & fertilization -bone growth
vitamin A sources:
-animal liver, eggs, dark-green veggies, deep yellow fruits
beta-carotene ProVitamin A versions & functions:
-retinol & retinal = vision, sexual reproduction, bone heath, immune function -retinoic acid = cell differentiation, bone health, immune function
vitamin A toxicity:
-fatigue -loss of appetite -blurred vision -skin disorders -birth defects/spontaneous abortion
vitamin A deficiency:
-night blindness -xerophthalmia (blindness due to cornea hardening) -hyperkeratosis (excess keratin in hair follicles)
Selenium roles:
-antioxidant (gluatathione enzyme system) -thyroxine (thyroid hormones) -body temp
selenium sources:
-organ meats, pork, seafood, couscous, whole wheat spaghetti
selenium deficiency:
-kasha disease (heart) -kashin-beck disease (deforming arthritis) -impaired immunity
erythrocytes
-RBC -transport oxygen through the body
leukocytes
-WBC -key to immune system
platelets
-cell fragments that assist in blood clotting
plasma
-fluid portion of blood -maintains adequate blood volume
minerals essential to blood health:
-iron -zinc -copper
vitamin essential to blood health:
-vitamin K -B6 -folate -B12
iron function
-oxygen-carrying hemoglobin & myoglobin (muscle) -component of cytochromes (electron carriers within metabolic pathways for energy production from carbs, fats, & proteins)
mucosal block: iron
-iron is stored in intestinal trace/enterocyte mucosal cells (ferritin) -GI tract naturally sheds mucosal lining every 3-5 days == iron/ferritin is lost -“block” = excessive absorption is blocked
iron toxicity:
-accidental iron overdose is most common cause of poisoning deaths in children -nausea, vomiting, diarrhea -hemochromatosis = excessive absorption of iron
iron deficiency stages:
• stage 1: iron depletion, reduced ferritin level, no physical symtoms -stage 2: erythropoiesis, decreased iron transport, reduced production of heme, fatigue -stage 3: anemia, decreased production of RBCs, inadequate hemoglobin to transport oxygen
zinc funtions:
-enzymatic (heme synthesis) -maintains structural integrity & shape of proteins (zinc fingers) -regulates gene expression
mucosal block: zinc
-zinc is stored in from of metallothionein in intestinal enterocytes -mucosal block manages zinc storage