test 1
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cancer affects — (higher multicellular animals)
metazoans
Hallmark of cancer: shift to — (ATP production)
glycolysis
Hallmark of cancer: reproduce without — (signals)
growth factors
hallmark of cancer: ignore growth —-
inhibitors
hallmark of cancer: avoid —/suppress — response
detection, immune
hallmark of cancer: — replicative potential
unlimited
hallmark of cancer: promotes —, —, —, and —-
growth, survival, angiogenesis, invasiveness
hallmark of cancer: leave — (location)
primary tumor
hallmark of cancer: recruit — (resource)
blood supply
hallmark of cancer: genomic changes — (speed)
accelerate
hallmark of cancer: survive despite major — —
DNA damage
which hallmarks are relevant for tissues?
avoiding immune destruction, tumor promoting inflammation, activating invasion and metastasis, inducing angiogenesis
which hallmarks are relevant in isolated cells?
evading growth suppressors, sustaining proliferative signaling, deregulating cellular energetics, resisting cell death, genome inability and mutation, enabling replicative immortality
what cell types do cancers recruit to the TME?
fibroblast, lymphocyte, macrophage
what could happen if a mutation changes a protein sequence
overactive or inactive protein (or no change)
what could happen if a mutation changes gene expression
more or less of a given protein
what type of mutation drives the development of cancer
driver mutation
what type of mutation has no role in cancer
passenger mutation
are epigenetic changes mutations
no
are epigenetic changes genomic alterations/genomic changes
yes
epigenetic changes are more likely to be (activating/inactivating)
inactivating
does cancer have to exhibit all hallmarks
no
are hallmarks always acquired in the same order
no, but some tend to occur before others
does a cell become cancer after obtaining one hallmark
no, need multiple accumulated alterations