exam 2.1
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Which of the following [REDACTED] reactions is freely reversible in cellular conditions? glycolysis rxn 7 enzs + the chems
Glycolysis reactions Phosphoglucose isomerase: Glucose 6-phosphate to fructose 6-phosphate Aldolase: fructose 1,6-biphosphate to glyceraldehyde 3-phosphate Triose phosphate isomerase: Glyceraldehyde 3-phosphate to dihydroxyacetone phosphate Glyceraldehyde 3-phosphate dehydrogenase: Glyceraldehyde 3-phosphate to 1,3-biphosphoglycerate Phosphoglycerate kinase: 1,3-biphosphoglycerate to 3-phosphoglycerate Phosphoglycerate mutase: 3-phosphoglycerate to 2-phosphoglycerate Enolase: 2-phosphoglycerate to phosphoenolpyruvate
Which of the following amino acids CANNOT supply carbon for gluconeogenesis? (Select all that apply)
Leucine and Lysine
For gluconeogenesis to function, which enzymes from glycolysis [REDACTED]? (Select all that apply) can run backwards 7
Can run backwards: G6P to F6P via phosphoglucose isomerase, F16BP to GA3P via aldolase, GA3P to 1,3 Bisphosphoglycerate via GA3P dehydrogenase, 1,,3 Bisphosphoglycerate to 3PG by phosphoglycerate kinase, 3PG to 2PG via phosphoglycerate mutase, 2PG to PEP by enolase; triose phosphate isomerase - GA3P to DiHP
For gluconeogenesis to function, which enzymes from glycolysis [REDACTED]? (Select all that apply) will be bypassed 3
Hexokinase, phosphofructokinase, pyruvate kinase
For gluconeogenesis to function, which enzymes from glycolysis [REDACTED]? (Select all that apply) Need to be bypassed: 3
Hexokinase, phosphofructokinase, pyruvate kinase
Which of the following enzymes creates [REDACTED]-phosphoglycerate? 1,3-bisphosphoglycerate, 3-phosphoglycerate, 2-phosphoglycerate. 2 each
[1,3-bisphosphoglycerate]→ glyceraldehyde 3-phosphate dehydrogenase +PK [3-phosphoglycerate] → phosphoglycerate kinase + PM [2-phosphoglycerate] → phosphoglycerate mutase + enolase
As a pediatrician you are diagnosing an infant. The infant has hepatomegaly. Blood work shows significantly reduced levels of glucose and a blood pH that is low and threatening acidosis. Growth rate seems fine, but the child is just not thriving. In the suspected disease, what enzyme has failed? 2
Glucose-6-phosphatase -> Von Gierke’s Disease or None of the above NOT glucose-6-phosphatase dehydrogenase
What purpose does lactate dehydrogenase serve? Lactate is a dangerous material!
Lactate dehydrogenase helps maintain the activity of glyceraldehyde-3-phosphate dehydrogenase. bc it regenerates NAD+
As a pediatrician you are diagnosing an infant. The infant has hepatomegaly. Blood work shows significantly reduced levels of glucose and a blood pH that is low and threatening acidosis. Growth rate seems fine, but the child is just not thriving. As a result, you suggest…
…the patient should be tested for I Von Gierke Disease
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