biology 3
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cell communication types
• endocrine signaling • paracrine signaling • juxtacrine signaling • reciprocal induction
endocrine signaling
hormones travel through the bloodstream to faraway target cells
paracrine signaling
signals diffuse to nearby cells
juxtacrine signaling
• cells must touch • one cells signal binds directly to receptors on another cell
reciprocal induction
• two tissues signal back and fourth causing both to differentiate
cell migration
• movement of cells from one place to another • required for embryonic development and continues throughout life • errors can cause birth defects or embryo death
how does cell migration work
• signaling molecules trigger movement • actin filaments push the cell forward • actin interacts with myosin to contract and push the cell • chemical signals guide direction and speed • some cells move individually others move collectively like epithelial cells
pluripotency
• how many cell types a cell can become
pluripotent
• cane become almost any cell type • cannot form placenta • source of embryonic stem cells
multipotent
can become several related cell types
oligopotent
can become a few cell types
unipotent
can become only one cell type
totipotent
can form an entire organism including placenta zygotę and early divisions
cell specialization happens because
different genes are turned on or off
all cells have
the same DNA
differences in cells come from
differential gene expression
gene expression process
• transcription (gene is copied into mRNA) • mRNA leaves the nucleus • translation - ribosome reads mRNA - tRNA brings amino acids - amino acids link tg • protein is made - the amino acid chain folds and becomes a protein
DNA methylation
a methyl group (carbon w 3 hydrogens) is added to DNA, usually silencing or turning off the gene by blocking proteins needed for transcription
epigenetic regulation
the control of gene expression that occurs without a change in the underlying DNA sequence
histone modification
chemical changes to histone proteins that make DNA more or less accessible for transcription
changes like dna methylation and histone modification
• alter chromosome structure • make dna more or less accessible to RNA polymerase • can be inherited
transcription
copying DNA into RNA for gene expression
gene expression
• where the information in a gene is used to make a functional product, usually a protein. Think of it like this • Your DNA is a cookbook. • A gene is one recipe. • Gene expression is when the cell actually uses that recipe.
translation
• process where a cell uses mRNA to make a protein.