Autoimmune

Most abundant of ABs Activates complement proteins

Attached to epithelial cells Prevents microbes from crossing mucus membrane

Activates complement proteins Makes bacteria cells clump together

Never exposed to antigens When they are exposed, they will create a mold of the antigen that can be used to make antibodies

Immediate allergic rxns & parasites

Responsible for cell-mediated immunity where they kill targets directly or stimulate activity of other leukocytes

Active or passive

Large quantities of immune cells

Lymph nodes, spleen, tonsils, appendix, bone marrow, thymus

Latent period of 7-14 days following exposure before antibodies can be produced. Dominated by IgM with some IgG

Occurs upon subsequent exposure to an antigen. Antibodies appear faster because memory cells recognize antigen and can make a faster immune response.

Immune reaction to self-antigens

Immune reaction to tissues of another individual

The immune response NOT the antigen/allergen

Minutes to hours after exposure

Hours to appear, at severity days after re-exposure to antigen

Most rapid and severe rxn

IgE mediated Hay fever, allergies Immediate rxn

AB mediated Tissue-specific Immediate

Complement-mediated immune disorders Ag-AB complex deposited in tissues Immediate

T-cell mediated rxn Delayed rxn

Contained within particle too large to be phagocytosed or protected by a nonallergenic coat.

T-helper cells differentiate B cells into specific IgE-producing cells IgE antibodies attach to receptors on mast cells or basophils Allergen binds to cell-associated IgE Binding triggers degranulation of mast cells/basophils to release histamine

-Occurs 5-30 minutes after exposure, subsides within 60 -Mediated by mast cell degranulation