LIPIDS: Lipoprotein III
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NCEP Guideline Recommendations: LDL Cholesterol: Optimal Near Optimal Borderline High High Very High
Optimal <100 Near Optimal 100-129 Border line High 130 - 159 High 160 - 189 Very High >190
NCEP Guideline Recommendations: Total Cholesterol: Desirable Borderline High High
Desirable < 200 Borderline High 200-239 High >240
NCEP Guideline Recommendations: HDL Cholesterol: Positive Risk Negative Risk
Positive Risk < 40 Negative Risk > 60
NCEP Guideline Recommendations: Triglycerides: Normal Borderline High High Very High
Normal <150 Borderline High 150-199 High 200-499 Very High >500
NCEP Therapeutic Goals: LDL 1. CHD is present 2. No CHD, 2 or more risk 3. No CHD, No Risk
• < 100 • < 129 • < 159
NCEP Therapeutic Goals: Total Cholesterol
< 200
NCEP Therapeutic Goals: Triglycerides
< 150
NCEP Therapeutic Goals: HDL
> 60
Frederickson Classification of Hyperlipidemias: Increased Chylomicrons Creamy Top Layer
Type I Hyperlipoproteinemia / Familial Hyperchylomicronemia
Frederickson Classification of Hyperlipidemias: Increased LDL ; Clear
Type IIa Hyperlipoproteinemia / Familial Hypercholestrolemia
Frederickson Classification of Hyperlipidemias: Increased LDL and VLDL ; Clear
Type IIb Hyperlipoproteinemia / Familial Combined Hypercholestrolemia
Frederickson Classification of Hyperlipidemias: Increased IDL ; Turbid
Type III hyperlipoproteinemia / Familial dysbetalipoproteinemia
Frederickson Classification of Hyperlipidemias: Increased VLDL
Type IV hyperlipoproteinemia / Familial Hyperlipemia
Frederickson Classification of Hyperlipidemias: Increased VLDL and Chylomicrons ; Creamy at top, Turbid Bottom
Type V hyperlipoproteinemia / Familial Hypertriglyceridemia
Most common familial form of hyperlipoproteinemia
Type IIb Familial Combined Hyperlipidemia • Apo B100 increased. HDL decreased.
associated with VLDL and B100 overproduction in the liver
Hyperabobetalipoproteinemia
Secondary Lipoproteinemia can be caused from
No Problem, My DM HOP Nephrotic Syndrome Pancreatitis Myxedema Diabetes Mellitus Hypothyroidism Obesity Pregnancy
Hypolipoproteinemias: Decreased TC Decreased Trig LDL and Apo B100 ABSENT
Abetalipoproteinemia
Hypolipoproteinemias: Apo B100 and B48 are ABSENT Low TC Normal-Low Trig level
Hypobetalipoproteinemia
Hypolipoproteinemias: Severely Elevated Trig Low HDL
Hypoalphalipoproteinemia
Hypolipoproteinemias: HDL absent Mutation in ABCA1 gene on Chromosome 9
Tangier’s disease
hardening and narrowing of arteries
Arteriosclerosis
narrowing of arterial due to plaque build up ; deposition of cholesterol and Trigy
Atherosclerosis
phytosterols are absorbed and accumulates in plasma and peripheral tissues
Sitosterolemia