Exam 4 - Lecture 42-43, Adrenergic Agonists I + II

block Gaq -> no Ca increase -> smooth muscle dilation

blocks Gai -> increase Ca2 + cAMP production -> increase transmitter release and smooth muscle relaxation

blocks Gas -> no increase cAMP -> decrease heart muscle contraction, decrease renin secretion

for vascular relaxation effects, inhibit vasoconstriction and cause vasodilation

decrease HR contractility, conductor velocity and relaxation rate little vascular effect, but can have small degree of vasoconstriction contraindicated in patients with sinus sickness cause inhibition of renin release form kidneys

control BP during surgery and in treatment of pheochromocytomas

are used in primary hypertension and BPH major depressive disorder, PTSD

have limited clinical usefulness; limited benefit in male ED

variety of clinical conditions and are firmly established in treatment of hypertension, ischemic heart disease, arrhythmias, endocrinology and neurologic disorders, glaucoma, and other conditions

severe pain in chest, due to inadequate blood supply to heart. beta blockers decrease contractility, cardiac work and oxygen demand

beta blockers used as secondary prevention, reducing infarct size, risk of ventricular fibrillation and decrease overall risk of death beta blocker reduce HR,BP and contractility

abnormalities in cardiac muscle contractions or normal rhythm of the rate of rate heart beat. Beta blockers may stop the dysrhythmia, primarily used to slow down heart rate during dysrhythmia. beta blocker reduce HR,BP and contractility

cardiac output is insufficient to meet metabolic demand leading to fluid build up around the heart. Beta blockers block harmful activation of the SNS or renin-angiotensin system beta blocker reduce HR,BP and contractility

treatment with beta blockers useful for reducing cardiac output, reduction of renin release form kidney, and decrease of sympathetic activity beta blocker reduce HR,BP and contractility

tumor in medulla of adrenal gland which produces large amounts of catecholamines localized using CT scan or MRI with MIBG

enlarged prostate gland leading to decreased urine output a antagonist used to relax prostate and bladder smooth muscle, but do not decrease the size of prostate

disease of optic nerve causing cupping of optic disc leading to loss of vision Beta blockers used to decrease intraocular pressure

“thyroid storm” increased thyroid hormone production and secretions resulting in increased heart rate, tremors, and nervousness nonselective beta blockers treat increase HR and tremors

non specific beta blockers treat symptoms

a antagonist and B blockers clinically used to alleviate symptoms

beta blockers = prophylactic treatments of migraines

phenoxybenzamine Phentolamine

-osin’s indoramin urapidil

yohimbine