CT and Adhesion

types of CT - 6 types

Sparse extracellular matrix of hyaluronan and proteoglycans supported by few collagen fibrils and elastic fibrils

examples of LCT

Predominately collagen fibers and a few fibroblasts. can be elastic

where is DCT found

which CT is mostly cells? which CT is mostly fibers?

• Covers the articular surfaces of joints, supports airways (trachea), skeletal appendages such as nose and ears • ECM consisting of collagen fibrils and high concentrations of proteoglycans and glycosaminoglycans

synthesize and secrete macromolecules that make up cartilage

25% of the dry mass of cartilage

75% of catalog, absorb water, which strengthens the cartilage and makes it resistant to compression

Composite material of collagen fibrils (tensile strength) embedded in a matrix of calcium phosphate (rigidity)

type 1 collagen fibrils and calcium phosphate

cells that secrete bone

an osteoblast that has enclosed itself with bone matrix

giant multinucleated cells that specialize in bone resorption

process of bone remodeling

bone fracture healing

2 genes that have genetic control for the formation of skeleton

hormonal control of formation of skeleton

Thinning of the bone Common in the elderly 50% of women will suffer from an osteoporosis related fracture during their life Cause is unknown – nutrition, activity, vitamin D, genetic variation in type I collagen gene

Failure of bone resorption Too much bone Fatal due to bone marrow failure Recessive mutations in proton ATPase pumps or chloride channels

Congential fragile bone syndrome All patients have a mutations in the gene for type I collagen

cell adhesion is important in (5)

molecules involved in adhesion