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13. Therapeutic Drug Monitoring

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Total cards: 24•Content version: v4•Public deck•Updated: 8/1/2026

Card preview (24)

#1
Front (Question)

Drug category? • phenytoin • valporic acid

Back (Answer)

anti-epileptics

#2
Front (Question)

Half-life of methotrexate

Back (Answer)

8-10 hrs

#3
Front (Question)

Drug category? • thiopurines • methotrexate

Back (Answer)

antimetabolites

#4
Front (Question)

Number of half-lives to reach steady state

Back (Answer)

5-7 half-lives

#5
Front (Question)

Folic acid antagonist; mimics DNA nucleotides

Back (Answer)

methotrexate

#6
Front (Question)

Drug category? • digoxin • lidocaine

Back (Answer)

cardioactive

#7
Front (Question)

Relaxes smooth muscle cells surrounding bronchioles

Back (Answer)

theophylline

#8
Front (Question)

Drug category? - theophylline

Back (Answer)

bronchodilator

#9
Front (Question)

4 methods/organs for drug excretion

Back (Answer)

Liver - total metabolism Kidneys - via urine (water-soluble) Bile and feces - for lipid-soluble Lungs - volatile metabolites

#10
Front (Question)

Drug category? • cyclosporine • tacrolimus

Back (Answer)

immunosuppressants

#11
Front (Question)

Half-life of vancomycin

Back (Answer)

6 hrs

#12
Front (Question)

3 reasons why a drug level may be falsely low and require a recovery dilution

Back (Answer)

• interfering substances • non-compliance • hook effect

#13
Front (Question)

When are ‘peak’ samples usually drawn for oral, IV, and IM after administration?

Back (Answer)

Oral = 2 hrs IV = 30 mins IM = 1 hr

#14
Front (Question)

4 factors that affect drug disposition

Back (Answer)

Absorption Distribution Metabolism Excretion

#15
Front (Question)

5 common analytical methods for determination of therapeutic drugs

Back (Answer)

MR HEG Mass spec Radioimmunoassay HPLC Electrophoresis Gas liquid chromatography

#16
Front (Question)

Half-life of theophylline

Back (Answer)

8 hrs

#17
Front (Question)

Number of half-lives required to eliminate 99% of a drug

Back (Answer)

7.5 half-lives

#18
Front (Question)

Half-life of lithium

Back (Answer)

22 hrs

#19
Front (Question)

Half-life of cyclosporine

Back (Answer)

4-6 hrs

#20
Front (Question)

Half-life of digoxin

Back (Answer)

40 hrs

#21
Front (Question)

3 factors that influence absorption of drug

Back (Answer)

• drug interactions • solubility • food or co-administered drugs

#22
Front (Question)

Used for treating leukemias, lymphomas

Back (Answer)

Methotrexate

#23
Front (Question)

Concentration range of the drug in blood where the drug has been shown to be effective without causing toxic effects in most people

Back (Answer)

Therapeutic range

#24
Front (Question)

Example of an inhibition metabolism

Back (Answer)

Morphine vs alcohol (compete for same enzyme active site)