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Vertebrate limb development

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Total cards: 15•Content version: v4•Public deck•Updated: 8/1/2026

Card preview (15)

#1
Front (Question)

What are Tbx5 and Tbx4 required for?

Back (Answer)

Tbx5-> forelimb Tbx4-> hindlimb

#2
Front (Question)

What does the Hox code do?

Back (Answer)

The hox code controls the expression of the Tbx5 and Tbx4 (by inducing RA)

#3
Front (Question)

What controls the production of FGF and what does it do?

Back (Answer)

The Tbx genes control production of FGFs FGFs initiate limb development

#4
Front (Question)

What happens when FGF is applied to the posterior interlimb region?

Back (Answer)

Leg buds develop

#5
Front (Question)

What gene is required for Tbx4 expression?

Back (Answer)

Pitx1

#6
Front (Question)

What does FGF10 expression induce?

Back (Answer)

FGF8 expression in the overlying ectoderm that will form the AER

#7
Front (Question)

The AER is necessary for the ….

Back (Answer)

Progress zone

#8
Front (Question)

What are the 2 models for proximal-distal patterning of the limb?

Back (Answer)

• Progress zone model 2. Two signal model

#9
Front (Question)

How does the ZPA control antero-posterior patterning?

Back (Answer)

It is a source of the Shh morphogen- digits specified at different concentrations of Shh

#10
Front (Question)

Which gene codes for the stylopod?

Back (Answer)

Meis

#11
Front (Question)

Which gene codes for the Zeugopod?

Back (Answer)

Hox11

#12
Front (Question)

Which gene codes for the autopod?

Back (Answer)

Hox13

#13
Front (Question)

What is the stylopod?

Back (Answer)

The humerus

#14
Front (Question)

What is the zeugopod?

Back (Answer)

The ulna and radius

#15
Front (Question)

What is the autopod?

Back (Answer)

The carpals and the digits