Magnesium
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Deficiency of magnesium caused by
Malnutrition Malabsorption Renal loss Endocrinological disturbances
Complications associated with decreased magnesium concentrations are
Neuromuscular irritability (tremor, seizures) Cardiac symptoms (Tachycardia and arrhythmia)
Decreased magnesium concentrations are often related to
Decreased calcium and potassium levels, taking into account that hypomagnesemia may be the primary cause of hypocalcemia.
Elevated magnesium values can be observed in
Dehydration Renal disorders After intake pf excessive amounts of antacid and can be associated with weakness of reflexes and low blood pressure
Method
Photometric test using xylidyl blue
Principle
Magnesium ions form a purple colored complex with xylidyl blue in alkaline solution. In presence of GEDTA, which complexes calcium ions, the reaction is specfic. The intensity of the purple color is proportional to the magnesium concentration.
Reagent:
Ethanolamine pH 11.0 GEDTA (Glycoletherdiaminetetraacetic acid) Xylidyl blue
Reagent contains
Ethanolamine.
Specimen
Serum, plasma, cerebrospinal fluid (CSF) or urine
Conversion factor
0.4114 = Magnesium [mmol/L]
Reference Range
Serum/Plasma: Neonates - 1.2 - 2.6 mg/dL (0.48 - 1.05 mmol/L) Children - 1.5 - 2.3 mg/dL (0.60 - 0.95 mmol/L) Women - 1.9 - 2.5 mg/dL (0.77 - 1.03 mmol/L) Men - 1.8 - 2.6 mg/dL (0.73 - 1.06 mmol/L) Urine: 73 - 122 mg/24 h - (3 - 5 mmol/24 h) CSF: 2.1 - 3.3 mg/dL (0.85 - 1.35 mmol/L)
Wavelength
520 nm (Increased) 628 nm (Decreased)