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Calculations

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Total cards: 16•Content version: v4•Public deck•Updated: 8/1/2026

Card preview (16)

#1
Front (Question)

Pharmacokinetic calculations Henderson-Hasselbach equation

Back (Answer)

Acid: PH= PKa + log(unionised/ionised) Bases: PH= PKa + log(ionised/unionised)

#2
Front (Question)

Pharmacokinetic calculations Absolute bioavailability

Back (Answer)

F= Dose/ AUC (iv) x AUC (oral)/dose

#3
Front (Question)

Pharmacokinetic calculations Rate of absorption, Ka

Back (Answer)

Ka= ln(2) / T1/2

#4
Front (Question)

Pharmacokinetic calculations Half-life

Back (Answer)

T1/2= 0.693/K

#5
Front (Question)

Pharmacokinetic calculations Volume of distribution, Vd

Back (Answer)

Vd= amount of drug administered/ blood plasma concentration Units of Vd= L or L/Kg

#6
Front (Question)

Pharmacokinetic calculations Loading dose, LD

Back (Answer)

LD= Vd x Desired plasma concentration/ S x F S= salt factor, 1 F= Bioavailability

#7
Front (Question)

Pharmacokinetic calculations Total clearance, CL

Back (Answer)

CL (systemic)= CL (renal) + CL (hepatic) + CL (other) CL= Vd x 0.693/T1/2 CL= ER x Q ER= Extraction ratio, Q= organ blood flow

#8
Front (Question)

Pharmacokinetic calculations Extraction ratio, ER

Back (Answer)

ER= eliminated drug/ eliminated drug + drug which escaped elimination

#9
Front (Question)

WBE calculations Load

Back (Answer)

Load= concentration x flow x (100/100+ stability) x (100/100 - sorption) sorption and stability as a %

#10
Front (Question)

WBE calculations Consumption

Back (Answer)

Consumption= Load x (1/Excretion) x (MWpar/MWDTR) x (1000/ population) - OS Excretion not as a % write as a decimal

#11
Front (Question)

Alcohol calculations Conversions between breath, blood and urine alcohol concentrations

Back (Answer)

Breath –> Blood –> Urine x2.3 x1.3375

#12
Front (Question)

Alcohol calculations Peak alcohol concentration, C

Back (Answer)

C = a x 100 / p x r C= mg/100ml a= mass of alcohol, g p= weight, Kg r= gender widmark factor (men=0.68, women= 0.56)

#13
Front (Question)

Alcohol calculations Calculating Mls and g of alcohol

Back (Answer)

ml of drink x (ABV% / 100)= Mls of alcohol Mls of alcohol x 0.789= g of alcohol

#14
Front (Question)

Alcohol calculations Elimination

Back (Answer)

Low range: 9 x time between incident and sample taken Medium range: 19 x time between incident and sample taken High range: 29 x time between incident and sample taken

#15
Front (Question)

Alcohol calculations Range of BAC

Back (Answer)

Low range: Peak alcohol concentration - low elimination Medium range: Peak alcohol concentration - Medium elimination High range: Peak alcohol concentration - High elimination

#16
Front (Question)

Alcohol Concentration Back calculation

Back (Answer)

Low range: blood sample result + low elimination value Medium range: blood sample result + medium elimination value High range: blood sample result + high elimination value