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Gut crypt cells

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Total cards: 7•Content version: v4•Public deck•Updated: 8/1/2026

Card preview (7)

#1
Front (Question)

What are the cells associated with a mammalian gut crypt?

Back (Answer)

Mesenchymal cells Basement membrane Paneth cells Stem cells (Crypt base columnar cells) Transit amplifying cells (TA)

#2
Front (Question)

What do CBCS selectively express?

Back (Answer)

Wnt target genes

#3
Front (Question)

What are Wnt target genes?

Back (Answer)

Lgr5/ GPR49

#4
Front (Question)

Which signals are needed to maintain epithelial stemness?

Back (Answer)

Wnt, Notch, EGF)

#5
Front (Question)

What signal negatively regulates stemness?

Back (Answer)

BMP

#6
Front (Question)

What are the 3 applications of creating a mini gut?

Back (Answer)

• Experimental tool • Diagnostic tool • Therapeutic tool

#7
Front (Question)

What are the steps in making a mini gut?

Back (Answer)

• Lrg5+ cells are genetically labelled by EGFP- sorted and embedded in matrigel • A single SC forms a cyst- bud formation occurs- symmetry is broke, structure resembles a crypt • Organoids adhere to de-epitheliazed wound bed, forms a flat epithelial layer, followed by crypt reconstruction • Wnt5+ mesenchymal cells support crypt formation in the damaged area