Week 4
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induced immune response
more delayed (4 days) governed by macrophages, neutrophils and ILCs
innate lymphoid cells
ILCs NK cells Helper ILCs (cytokine factories) tissue inducer cells (reg dev of 2º lymph tissue)
inflammatory cytokines
mobilize the IR to site of infection hot, red, painful inflammation
maintains inflammatory response
macrophages monocytes dendritic cells granulocytes NK cells
immune receptors
exist in 100s of isoforms can combine for vast diversity in detecting capabilities
bacterial and fungal surface carb receptors
100s of receptor types, called lectins located on macrophages
viral glycoproteins
ex: toll-like receptors (TLRs) need to overcome human appearance of viral carbs
tissue resident macrophages
initially deposited to all tissues during embryonic dev replaced by hematopoietic SC
tissue resident macrophage MoA
intercept pathogen receptor-mediated endocytosis lysosomal degradation
neutrophils
leukocyte descendents released from BM to circ in humeral system 1st responders, use phagocytosis
apoptosis
programmed cell death genetically inherited important for cellular pruning
necrosis
perterburation of cell viability dt damage
NETosis
regulated cell death dependent on the formation of neutrophil extracellular traps (NET)
types of innate receptors
pattern recognition receptors damage associated molecular pattern receptors scavenger receptors
pattern recognition receptors
PRR recog pathogen structural features pathogen associated molecular pattern (PAMP)
damage associated molecular pattern
DAMP detect aspects of damaged cells
scavenger receptors
SR stim phagocytosis, cell adhesion and downstream signalling 11 classes A-L
toll-like receptors
TLR present on immune cells to respond to pathogens via innate response recog lipid prots and polysaccharides signal to transcription fx
group 1 TLR
TLR4 membrane bound on cell surface recog carb, lipid and prot ligands
group 2 TLR
TLR3, 7-9 membrane bound in endosome recog pathogenic nucleic acids
nucleotide-binding and oligomerization domain receptors
NOD work intracellularly soluble cytoplasmic receptors detect IC prod of bac degradation
interferon triggers
viral cytoplasmic signatures transcriptional remnants translational prod new viral genetic mat
type I interferons
distrupt viral replication instruct adjacent cells to prep for infection signals effector immune cells
dendritic cell interferon prod
plasmacytoid dendritic cells (PDC) prod type I interferons 1000x greater interferon prod express TLR 7 and 9