Endocrine: Testosterone
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most potent male androgen
Testosterone
Testosterone is synthesized in
DHEAS
Testosterone is regulated by
LH and FSH
Testosterone Peak Low
Peak 8:00am Low 8:00 pm
Development of male characteristics Spermatogenesis in Sertoli Cells
Normal development of Sperm cells
Urinary Metabolite of Testoterone
17-Ketosteroids Method: Zimmerman Reaction
Principal androgen formed by adrenal cortex ; weak androgen
DHEAS
Increased LH and FSH Decreased Testosterone
Hypergoandrotropic Hypogonadism
Klinefelter’s Syndrome Testicular Feminization Syndrome 5a Reductase Deficiency Myontic Deficiency Testicular Injury and Infection Sertoli cell only Syndrome
Hypergoandrotropic Hypogonadism
Decreased LH and FSH Decreased Testosterone
Hypogoadotropic Hypogonadism
Azoospermia; Deficient Verilization; Hermaphrodism
Hypogoadotropic Hypogonadism
Kallman’s syndrome Type 2 Diabetes Hyperprolactinemia Pituitary Disease
Hypogoadotropic Hypogonadism
impotence, loss of secondary sex characteristics, delayed puberty results
Hypoandrogenemia
include infections, tumors, congenital disordersd
Primary Hypoandrogenemia
Klinefelter’s Syndrome
Primary Hypoandrogenemia
possess extra X chromosome XXY
Klinefelter’s syndrome
Hypofunction disorders pituitary and hypothalamus; decreased synthesis LH and FSH
Secondary Hypoandrogenemia