Anasethesia, Analgesia, and Euthanasia
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Why are anaesthesia and analgesia used?
• legislative reasons • ethical reasons • technical reasons (animals are still) • benefit of reasearch
Which classes must be anaesthetised before it is caused physical or mental suffering?
• mammals • birds, • reptiles • amphibians • fish • cyclostomatous (Rundmäuler; Wirbeltiere) • cephalopodan (Oktopus)
What are the goals for anaesthesia?
• Senstivie block –> absence of pain (analgesia) • motoric block –> relaxation of muscles • mental block –> sleep/loss of consciousness • autonomic block –> vagal inhibition (no salvation, slow HR)
What are the components of balanced anaesthesia?
• premedication • induction • maintenance • postoperative • recovery
Drugs in premedication - combinations of
• sedatives • calming • (anti-cholinergics - reduce salvation, parasympathicus) • ((muscle relaxants)) • pain relief
Different working levels of pain relief
• Local anasethetic • anti-inflammatory - periphery • morfin and syntetic opiods - centrally • calming (benzos) • good anasethesia
Name some advantages of inhalation anaesthesia
• good control • limited biotransformation • easy to regulate the depth • quick induction and wake up
Name some disadvantages of inhalation anaesthesia
• large investment (equipment) • know-how • ventilation
Name some advantages with injectable drugs
• no special equipment • cheap • simple techniques • no effect on working environment • easier for batch anaesthesia
Name some disadvantages of injectable drugs
• once a given dose is adminstered, the anaesthetic cannot be changed • duration of anaesthetic effect is patient dependent • individual variability for a given dose • some injectable agents are irritating • many lack an antidote • often long induction and wake up time
From where do you take blood samples in a mouse?
Tail vein or vena saphena on the hind leg (outside of leg)
Where do you sample blood in rats?
Teil vein or vena saphena on the hind leg
Where do you sample blood from guinea pig?
Vena saphena on the hind leg
Where do you sample blood from rabbits?
The margin vein of the ear
Name five signs of inflammation
• calor (heat) • rubor (redness) • tumor (swelling) • dolor (pain) • functio laesa (loss of function)
Name possible causes for inflammation
• infectious: bacteria, virus, fungi or parasites • trauma • physical or chemical agents • foreign body • tissue necrosis (ischemic) • immune reaction
What parameters can you use to recognise pain in animals?
• Behaviour • eating • drinking • activity • twiches • vocalisation • hormonal changes • body weight
Name some characteristics of the pain face in rabbits
• orbital tightening • cheek flattening • nose shape • whisker position • ear position
Name some pain face characteristics of mice
• orbital tighetening • nose bulge • cheek bulge • ear position • whisker change
Name some negative effects of pain
• prolonged wound healing • slow recovery with higher chance of post-operative complications • wound biting and auto-mutilation • higher variability in the experimental group • immunological disturbances • less water- and food intake • less efficient respiration • sensitisation –> chronic pain
Which properties should acceptable methods of euthanasia process?
• cause rapid loss of consciousness • be painless • be easy to perform • be minimally invasive
Name chemical methods for euthanasia
• inhalation anasethetics • inhalation (CO2) • injection (barbiturates)
Name phyisical methods of euthanasia
• cervical dislocation • decapitation (anaesthetised animals!) • blow to the head • crush the brain • microwave
Which form of euthanasia can be used for all animals?
Overdose of anaesthetics and confirm death