Chap 9: Lipid Metabolism
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Building Block of Fatty Acid
Acetyl CoA
Lipoids
Phospholipids Glycolipids Cholesterol Cholesterol ester
Lipoids are important for
Membrane components
Triglyceride or triacylglycerole are used to
store and supply energy
Lipids have (chain and groups)
hydrocarbon chain and ester group
Lipid composed by
ester of fatty acid (C - O - C)
Lipid Metabolism
Lipolysis Lipogenesis Beta Oxidation Formation of Ketone Bodies
Lipogenesis (Divided into 3 Processes)
Biosynthesis of glycerol Biosynthesis of Fatty Acids Biosynthesis of the Triacylglycerol
Lipogenesis occurs in
(Mostly) adipose tissue, liver, lactating mammary glands, brain
Lipogenesis occurs in
(Mostly) adipose tissue, liver, lactating mammary glands, brain
7 malonyl-CoA (Part 1 of Bio. Tria)
7 Acetyl-CoA + 7CO2 + 7ATP
Acetyl-CoA + 7 malonyl CoA (+ 7ATP) (Part 2 of Bio Tria)
Palmitic Acid
The synthesis of long-chain FA carried out by my 2 enzyme system present in cytoplasm of cell
Acetyl CoA carboxylase FA synthase complex
One glucose produces Each acetyl CoA contains 4 glucose molecules
2 Acetyl CoA 2 Carbon are required to produce 16 carbons of palmitic acid
• Dehydrogenation
loss of hydrogen to form a C=C double bond
• Hydration
the addition of water across the C=C double bond
• Oxidation
loss of electrons and the formation of ketone C=O
• Thiolysis (breaks sulfur)
the splitting of coenzyme-A activated fatty acids
Adipose cells are specialized for
synthesis and storage of triacylglycerol
The TG stored in the adipocytes are hydrolyzed by lipases to produce free FA and glycerol which are released to the blood
Fat mobilization
Hormone-sensitive lipase (HSL)
TG lipase is the rate-limiting enzyme in the TG degradation in adipose tissue
Lipolytic Hormones
• Epinephrine • Norepinephrine • Adrenocorticotropic Hormone (ACTH) • Thyroid-stimulating Hormone (TSH) Glucagon *
Lipolytic Hormones
• Epinephrine • Norepinephrine • Adrenocorticotropic Hormone (ACTH) • Thyroid-stimulating Hormone (TSH) Glucagon*
Anti-lipolytic hormone (Against fat breakdown)
Insulin (Opposite to Glucagon) (Stores fat)