Carboxylic Acid Reactions
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how do we compare the acidities of organic compounds with electronegative substituents; hint : 3 things
degree of electronegativity, number and proximity
true or false - pKa increases when the electronegativity of substituent increases
true
true or false - pKa decreases when the distance from the electronegative atom increases
false - pKa increases
what are the two ways a carboxylic acid can be converted into a ester
Fischer esterification and Sn2
what is the Fischer esterification reaction
carboxylic acid + alcohol => ester + water
which of the carboxylic acid derivatives can hydrogen bond
amides
what is the most reactive carboxylic acid derivative
acid chloride
what are the three reactions of acid chlorides and their products
• acid chloride + carboxylate => anhydride • acid chloride + alcohol + non nucleophilic base => ester • acid chloride + amine => amide
how is a acidic anhydride produced
two carboxylic acids + heat